CHO starter cell lines for manufacturing of proteins with pre-defined glycoprofiles
نویسندگان
چکیده
منابع مشابه
CHO starter cell lines for manufacturing of proteins with pre-defined glycoprofiles
Backround Glycosylation of protein therapeutics is influenced by a multifaceted mix of product intrinsic properties, host cell genetics and upstream process parameters. Industrial CHO cell lines may have several deficits in their glycosylation pattern for some applications, like high fucose content (corresponding to a low ADCC profile) and low galactosylation and sialylation levels (proposed to...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2013
ISSN: 1753-6561
DOI: 10.1186/1753-6561-7-s6-p96